Item Number：C3440
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Specification & Item NumberC3440-0020 (20ml)
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Storage Conditions-20ºC
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Conditions Carriagedry ice
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Validity Period (Months)18
Product Introduction
Nystatin is a mixture of antimycotic polyenes, like amphotericin B, and is used in cell culture for the control of fungi, yeasts and molds. Like many other antifungals and antibiotics, this polyene macrolide antimycotic, generally termed nystatins, are of bacterial origin. Nystatin has been isolated from the soil actinomycete, Streptomyces noursei. The mode of action (MOA) of this family is exhibited by its ability to bind to steroidal alcohols (e.g., cholesterol, cholestanol), specifically ergosterol, in the cell membrane of susceptible fungi by creating transmembrane channels (ionophore) in the cell membrane per se thereby increasing membrane permeability.
The Minimum Inhibitory Concentration (MIC) for nystatin-sensitive fungi is reportedly to be in the range of 1.56 - 6.25 μg/mL.
The resultant loss of cations (e.g., K+, Na+, H+), and/or other low molecular weight substances including sugars, amino acids or nucleotides, the increase or amplification of Na+ /K+ pump activity in addition to the inhibitory effect through these channels on the extracellular membrane-bound enzymes, collectively and in concert, all contribute to the demise of these types of organisms. Nystatin is primarily fungistatic at low concentrations against biphasic fungi, Dermatophyta and molds. It is also effective against yeasts.
The Minimum Inhibitory Concentration (MIC) for nystatin-sensitive fungi is reportedly to be in the range of 1.56 - 6.25 μg/mL.
The resultant loss of cations (e.g., K+, Na+, H+), and/or other low molecular weight substances including sugars, amino acids or nucleotides, the increase or amplification of Na+ /K+ pump activity in addition to the inhibitory effect through these channels on the extracellular membrane-bound enzymes, collectively and in concert, all contribute to the demise of these types of organisms. Nystatin is primarily fungistatic at low concentrations against biphasic fungi, Dermatophyta and molds. It is also effective against yeasts.
Product Application
Nystatin is primarily fungistatic at low concentrations against biphasic fungi, Dermatophyta and molds. It is also effective against yeasts.
Production And Quality System
Manufacturing in accordance with cGMP guidelines, in accordance with ISO13485 production standards.
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